Promethazine HCl Oral Answer must be utilized with caution in patients with bone-marrow depression. Leukopenia and agranulocytosis have already been noted, ordinarily when Promethazine (Promethazine HCl) continues to be Utilized in association with other identified marrow-poisonous agents.
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are Expecting or program to be Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Answer can harm your unborn newborn. See “What exactly is The key details I really should understand about Promethazine Hydrochloride and Codeine Phosphate Oral Solution?” are breastfeeding or intend to breastfeed. Codeine passes into your breast milk and can result in major Negative effects with your newborn together with elevated sleepiness, breathing issues (respiratory depression), and death. It isn't recognized if promethazine can pass into your breast milk.
Antiemetics usually are not encouraged for therapy of uncomplicated vomiting in pediatric individuals, as well as their use really should be limited to prolonged vomiting of regarded etiology. The extrapyramidal signs or symptoms which could take place secondary to Promethazine HCl Oral Answer administration may very well be perplexed Together with the CNS signs of undiagnosed Key condition, e.g., encephalopathy or Reye's syndrome. The usage of Promethazine HCl Oral Solution really should be avoided in pediatric clients whose indicators and indications could suggest Reye's syndrome or other hepatic conditions.
Promethazine is metabolized because of the liver to a variety of compounds; the sulfoxides of Promethazine and N-demethylpromethazine are classified as the predominant metabolites showing up from the urine.
Prescription drug abuse may be the intentional non-therapeutic use of a prescription drug, even as soon as, for its worthwhile psychological or physiological effects.
If this SPL is made up of inactivated NDCs mentioned by the FDA initiated compliance motion, They are going to be specified as a result.
Kids Postmarketing circumstances of respiratory melancholy, which includes fatalities, have been reported with utilization of promethazine in pediatric sufferers. Concomitant administration with other respiratory depressants could improve the danger of respiratory melancholy.
Promethazine is contraindicated in comatose states, and in people acknowledged for being hypersensitive check here or to have experienced an idiosyncratic response to promethazine or to other
In case the response to an opioid antagonist is suboptimal or only transient in character, administer more antagonist as directed by the product’s prescribing details. The respiratory depressant outcomes of promethazine are usually not reversed by opioid antagonists, like naloxone.
It is strongly recommended that an exact measuring machine be made use of. A pharmacist can offer an acceptable unit and can offer Recommendations for measuring the correct dose.
Promethazine is actually a phenothiazine by-product which differs structurally with the antipsychotic phenothiazines via the existence of the branched facet chain and no ring substitution.
The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and slightly soluble in Liquor.
Promethazine HCl Oral Answer can be used on your own or as an adjunct to narcotic analgesics all through labor (see DOSAGE AND ADMINISTRATION). Limited info advise that usage of Promethazine HCl Oral Solution in the course of labor and shipping doesn't have an considerable impact on the length of labor or shipping and won't enhance the risk of need for intervention within the newborn.